Course Name | Gene Therapy |
Code | Semester | Theory (hour/week) | Application/Lab (hour/week) | Local Credits | ECTS |
---|---|---|---|---|---|
GBE 440 | Fall/Spring | 3 | 0 | 3 | 5 |
Prerequisites | None | |||||
Course Language | English | |||||
Course Type | Elective | |||||
Course Level | First Cycle | |||||
Mode of Delivery | - | |||||
Teaching Methods and Techniques of the Course | DiscussionGroup WorkLecturing / Presentation | |||||
Course Coordinator | ||||||
Course Lecturer(s) | ||||||
Assistant(s) | - |
Course Objectives | The objective of this course is to introduce students the viral and nonviral gene transfer techniques and the molecular basis of these techniques. In this course, recent gene therapy applications in hereditary and acquired diseases will be explained and the importance of gene therapy as a therapeutic strategy will be discussed. |
Learning Outcomes | The students who succeeded in this course;
|
Course Description | Gene therapy, viral and non-viral gene delivery techniques |
Related Sustainable Development Goals | |
| Core Courses | |
Major Area Courses | ||
Supportive Courses | ||
Media and Managment Skills Courses | ||
Transferable Skill Courses |
Week | Subjects | Required Materials |
1 | Introduction to gene therapy | A Handbook of Gene and Cell Therapy - Chapter 1 |
2 | Non-viral Vectors for Gene Therapy | A Handbook of Gene and Cell Therapy - Chapter 2 |
3 | Viral Vectors for Gene Therapy-1 | A Handbook of Gene and Cell Therapy - Chapter 3 |
4 | Viral Vectors for Gene Therapy-2 | A Handbook of Gene and Cell Therapy - Chapter 3 |
5 | Barriers to Gene Delivery | A Handbook of Gene and Cell Therapy - Chapter 4 |
6 | Stem Cells and Tissue Regeneration-1 | A Handbook of Gene and Cell Therapy - Chapter 5 |
7 | Midterm | |
8 | Stem Cells and Tissue Regeneration-2 | A Handbook of Gene and Cell Therapy - Chapter 5 |
9 | Gene Therapy Strategies: Gene Augmentation | A Handbook of Gene and Cell Therapy - Chapter 6 |
10 | Gene Therapy Strategies: Gene Silencing | A Handbook of Gene and Cell Therapy - Chapter 7 |
11 | Gene Editing | A Handbook of Gene and Cell Therapy - Chapter 8 |
12 | Gene Therapy Applications: Preclinical Studies and Clinical Trials | A Handbook of Gene and Cell Therapy - Chapter 9 |
13 | Gene Therapy for Cancer | A Handbook of Gene and Cell Therapy - Chapter 9 |
14 | Gene Therapy for Eye Conditions and Cardiovascular Diseases (CVDs) | A Handbook of Gene and Cell Therapy - Chapter 9 |
15 | Gene Therapy for Neurodegenerative Diseases | |
16 | Final exam |
Course Notes/Textbooks | An Introduction to Molecular Medicine and Gene Therapy 1st Edition by Thomas F. Kresina ISBNs: 0-471-39188-3 (Hardback); 0-471-22387-5 (Electronic) A Handbook of Gene and Cell Therapy. Authors: Nobrega, Clevio, Mendonça, Liliana, Matos, Carlos. ISBN 978-3-030-41333-0. 2020. |
Suggested Readings/Materials | An Introduction to Human Molecular Genetics (2nd Edition), J.J. Pasternak, 2005 A Handbook of Gene and Cell Therapy. Authors: Nobrega, Clevio, Mendonça, Liliana, Matos, Carlos. ISBN 978-3-030-41333-0. 2020. |
Semester Activities | Number | Weigthing |
Participation | ||
Laboratory / Application | ||
Field Work | ||
Quizzes / Studio Critiques | ||
Portfolio | ||
Homework / Assignments | ||
Presentation / Jury | 1 | 30 |
Project | ||
Seminar / Workshop | ||
Oral Exam | ||
Midterm | 1 | 30 |
Final Exam | 1 | 40 |
Total |
Weighting of Semester Activities on the Final Grade | 2 | 70 |
Weighting of End-of-Semester Activities on the Final Grade | 1 | 30 |
Total |
Semester Activities | Number | Duration (Hours) | Workload |
---|---|---|---|
Course Hours (Including exam week: 16 x total hours) | 16 | 3 | 48 |
Laboratory / Application Hours (Including exam week: 16 x total hours) | 16 | ||
Study Hours Out of Class | 14 | 2 | 28 |
Field Work | |||
Quizzes / Studio Critiques | |||
Portfolio | |||
Homework / Assignments | |||
Presentation / Jury | 1 | 20 | |
Project | |||
Seminar / Workshop | |||
Oral Exam | |||
Midterms | 1 | 24 | |
Final Exams | 1 | 30 | |
Total | 150 |
# | Program Competencies/Outcomes | * Contribution Level | ||||
1 | 2 | 3 | 4 | 5 | ||
1 | To have adequate knowledge in Mathematics, Science and Biomedical Engineering; to be able to use theoretical and applied information in these areas on complex engineering problems. | |||||
2 | To be able to identify, define, formulate, and solve complex Biomedical Engineering problems; to be able to select and apply proper analysis and modeling methods for this purpose. | |||||
3 | To be able to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the requirements; to be able to apply modern design methods for this purpose. | |||||
4 | To be able to devise, select, and use modern techniques and tools needed for analysis and solution of complex problems in Biomedical Engineering applications. | |||||
5 | To be able to design and conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or Biomedical Engineering research topics. | |||||
6 | To be able to work efficiently in Biomedical Engineering disciplinary and multi-disciplinary teams; to be able to work individually. | |||||
7 | To be able to communicate effectively in Turkish, both orally and in writing; to be able to author and comprehend written reports, to be able to prepare design and implementation reports, to present effectively, to be able to give and receive clear and comprehensible instructions. | |||||
8 | To have knowledge about global and social impact of Biomedical Engineering practices on health, environment, and safety; to have knowledge about contemporary issues as they pertain to engineering; to be aware of the legal ramifications of engineering solutions. | |||||
9 | To be aware of ethical behavior, professional and ethical responsibility; to have knowledge about standards utilized in engineering applications. | |||||
10 | To have knowledge about industrial practices such as project management, risk management, and change management; to have awareness of entrepreneurship and innovation; to have knowledge about sustainable development. | |||||
11 | To be able to collect data in the area of Biomedical Engineering, and to be able to communicate with colleagues in a foreign language. | |||||
12 | To be able to speak a second foreign language at a medium level of fluency efficiently. | |||||
13 | To recognize the need for lifelong learning; to be able to access information, to be able to stay current with developments in science and technology; to be able to relate the knowledge accumulated throughout the human history to Biomedical Engineering. |
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest